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Cetylpyridinium chloride ngati Chithandizo cha COVID-19

Kuyesaku kunawonetsa kuchuluka kwa mankhwala ophera tizilombo ta quaternary ammonium ngati mankhwala a ma virus ambiri, kuphatikiza ma coronaviruses: izi zimathandiza pakuletsa zotsekemera zamadzimadzi zomwe zimakutira ma virus monga SARS-CoV-2 amadalira. Ma quaternary ammonium compounds amalimbikitsidwa kupha ma virus ndipo pali zinthu zopitilira 350 pa Mndandanda wa EPA N: Mankhwala ophera tizilombo omwe angagwiritsidwe ntchito polimbana ndi SARS-CoV-2 (Supplementary Material. mankhwala omwe ali pamndandanda wa EPA anenedwa ndipo> 140 itha kutulutsa kachilomboka m'mphindi zochepa chabe (18).
Izi zidatitsogolera pakufufuza kwakukulu kwa mankhwala a quaternary ammonium omwe ali ndi zochita motsutsana ndi ma coronaviruses ndikuzindikira mankhwala omwe adayesedwa kale kuchipatala ndipo atha kugwiritsidwa ntchito ngati chithandizo cha COVID-19. Mmodzi mwa mankhwala ophera tizilombo omwe awonetsedwa kuti ndi owononga ma virus (Supplementary Material) ndipo amagwiritsidwa ntchito kwambiri pazinthu zosamalira anthu ndi cetylpyridinium chloride. Kampaniyi imapezeka makamaka mumatsuka m'kamwa ndipo imalembedwa ndi a FDA monga ambiri monga Safe (GRAS) kotero kuti imagwiritsidwanso ntchito ngati mankhwala opha tizilombo a nyama ndi nkhuku (mpaka 1%). Cetylpyridinium chloride yakhala ikugwiritsidwa ntchito m'mayesero angapo azachipatala, kuphatikiza chithandizo chamankhwala opatsirana omwe amatsimikizira kuti amagwiritsidwa ntchito ngati ma virus. Cetylpyridinium mwina imathandizira kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda. Izi zimadzutsa funso ngati mankhwala ena omwe amadziwika ndi ma ARV-SARV-2 mu vitro amakhalanso chimodzimodzi, mwina atha kuwononga kachilombo ka capsid komanso kudzipezera mu lysosome kapena endosomes ndikuletsa kulowa kwa ma virus. Kafukufuku wowonjezera wasonyeza kuti zotsatirazi zitha kuchepetsedwa pogwiritsa ntchito zoletsa za Cathepsin-L. 

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Cetylpyridinium mankhwala enaake (CPC)

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Quaternary ammonium mankhwala omwe amadziwika ndi coronavirus

Molecule

Ntchito yothandizira ma virus

Njira

FDA yovomerezeka

Ntchito

Ammonium mankhwala enaake Murine coronavirus, matenda a chiwindi C, Lysosomotropic Inde Ntchito zosiyanasiyana kuphatikiza kagayidwe kachakudya acidosis.
Cetylpyridinium mankhwala enaake Fuluwenza, hepatitis B, poliovirus 1 Amalimbitsa capsid ndipo ndi lysosomotropic Inde, GRAS Antiseptic, kutsuka pakamwa, lozenges, mankhwala osamalira anthu ena, oyeretsa etc.

Post nthawi: Apr-16-2021